Selective ghrelin receptor agonist. Minimal cortisol effect.
Product Information
- Compound: Ipamorelin
- Category: Growth hormone axis research
- Form: Lyophilized powder, single-use vial
Ipamorelin: Mechanism & Published Research
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that acts as a selective agonist of the ghrelin receptor (GHS-R1a). It was developed to overcome some of the selectivity limitations of earlier growth hormone-releasing peptides (GHRPs), particularly the elevation of cortisol and prolactin observed with GHRP-2 and GHRP-6 in pre-clinical and early clinical models.
In the published pharmacology literature, ipamorelin has been characterized as a selective GHS-R1a agonist with an approximately 7,500-fold lower affinity for adrenocorticotropic hormone (ACTH) secretion and approximately 10,000-fold lower stimulatory effect on prolactin release compared to GHRP-2 at equimolar concentrations. This selectivity profile has made ipamorelin a preferred research tool in growth hormone axis studies where investigators wish to isolate GH secretion effects from corticotrophic side effects.
Pharmacokinetic studies in rodent and porcine models have characterized ipamorelin's half-life at approximately two hours following subcutaneous or intravenous administration, making it suitable for pulsatile GH secretion research protocols. Researchers studying the somatotropic axis have used ipamorelin as a tool compound to examine GH pulse amplitude, IGF-1 downstream signaling, and GH-independent anabolic effects in various tissue models.
Ipamorelin is frequently studied in combination with growth hormone-releasing hormone analogs — particularly CJC-1295 (Mod GRF 1-29) — to produce synergistic GH pulse amplification in animal models. The combined GHRH + GHS approach has been examined extensively in the published growth hormone research literature as a means of more closely recapitulating the physiological GH secretory pattern.
Canada Peptide Supply offers ipamorelin in 5 mg and 10 mg lyophilized vials. Ipamorelin is not approved by Health Canada for therapeutic use and is sold strictly for in-vitro laboratory research by qualified investigators.
Research use only: this information is provided for scientific reference. Canada Peptide Supply does not provide medical advice. Ipamorelin is not approved by Health Canada for human consumption, diagnosis, treatment, or prevention of disease.
Batch documentation
Before ordering, contact us with the product name and selected size to ask which batch documentation is available. For an existing order, include the batch number on the label. Match any certificate to the exact batch and review the methods and results reported; a purity result alone does not establish sterility or suitability for human use. See our COA policy.
Shipping within Canada
Orders ship within Canada. Standard shipping is $24.99 CAD and express shipping is $49.99 CAD. Free standard shipping applies to a merchandise subtotal of $250 CAD or more; express shipping is not included. Review shipping, dispatch and returns before ordering. Transit estimates begin after dispatch.
Intended Use
This product is sold strictly for laboratory research, in-vitro testing, and analytical reference. It is not approved by Health Canada for human consumption, diagnosis, treatment, or prevention of disease. Buyer must be 21 years of age or older. By purchasing, you agree to our Terms of Sale.
Frequently asked about Ipamorelin
Is Ipamorelin legal in Canada?
Ipamorelin is sold as an in-vitro research compound. It is not approved by Health Canada for human use and is not a controlled substance in Canada. Qualified researchers may legally purchase it for laboratory research.
What does the published research report?
Study designs, routes and amounts vary widely between animal models. The research section above summarizes the published pharmacology. We do not provide dosing guidance for any human application.
What is your refund policy?
Refunds, replacements and damaged-order claims follow our shipping, dispatch and returns policy.
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