Copper peptide. The most-cited skin and hair research compound.
Product Information
- Compound: GHK-Cu
- Category: Skin and hair research
- Form: Lyophilized powder, single-use vial
- Supplier: Toronto-based Canadian supplier
GHK-Cu: Mechanism & Published Research
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex, CAS 49557-75-7, molecular formula C14H24N6O4Cu, molecular weight 403.9 g/mol) is a naturally occurring tripeptide-copper complex first identified in human plasma by Loren Pickart in the 1970s. It has since accumulated one of the largest published research bodies of any cosmetic peptide, with hundreds of peer-reviewed studies examining its biological activity across multiple tissue and cell models.
In the published literature, researchers have described GHK-Cu as a potent modulator of gene expression. Transcriptomic analyses have identified that GHK-Cu affects the expression of over 4,000 human genes in cell culture models, with observed effects on collagen synthesis, fibronectin production, decorin expression, and matrix metalloproteinase regulation. Investigators studying skin models have reported increased type I and III collagen production following GHK-Cu exposure in human dermal fibroblast cultures.
Hair follicle research has examined GHK-Cu’s role in stimulating dermal papilla cell activity and extending the anagen phase of the hair growth cycle in follicle organ culture models. Published pharmacokinetic studies suggest that the tripeptide-copper complex is stable in physiological conditions and is internalized by cells via endocytosis and copper transporter mechanisms.
Wound-healing research has investigated GHK-Cu’s effects on fibroblast migration, proliferation, and contraction in scratch assay models. Researchers have also examined potential anti-inflammatory properties via modulation of tumor necrosis factor-alpha and interleukin-6 pathways in macrophage models.
Canada Peptide Supply offers GHK-Cu in 50 mg and 100 mg lyophilized vials. GHK-Cu is not approved by Health Canada for therapeutic use and is sold strictly for in-vitro research purposes.
Research use only: this information is provided for scientific reference. Canada Peptide Supply does not provide medical advice. GHK-Cu is not approved by Health Canada for human consumption, diagnosis, treatment, or prevention of disease.
Batch documentation
Before ordering, contact us with the product name and selected size to ask which batch documentation is available. For an existing order, include the batch number on the label. Match any certificate to the exact batch and review the methods and results reported; a purity result alone does not establish sterility or suitability for human use. See our COA policy.
Shipping within Canada
Orders ship within Canada. Standard shipping is $24.99 CAD and express shipping is $49.99 CAD. Free standard shipping applies to a merchandise subtotal of $250 CAD or more; express shipping is not included. Review shipping, dispatch and returns before ordering. Transit estimates begin after dispatch.
Intended Use
This product is sold strictly for laboratory research, in-vitro testing, and analytical reference. It is not approved by Health Canada for human consumption, diagnosis, treatment, or prevention of disease. Buyer must be 21 years of age or older. By purchasing, you agree to our Terms of Sale.
Frequently asked about GHK-Cu
Is GHK-Cu legal in Canada?
GHK-Cu is a research peptide sold strictly for in-vitro laboratory research. It is not approved by Health Canada for any therapeutic indication. As a research compound it is legal for qualified researchers in Canada to purchase.
What does the published research report?
Concentrations and endpoints vary widely between cell and tissue models. Our GHK-Cu copper peptide research article summarizes the published work. We do not provide dosing guidance for human application.
What is your refund policy?
Refunds, replacements and damaged-order claims follow our shipping, dispatch and returns policy.
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